Article

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex

2021-12-21

Abstract excerpt

<h4>Summary</h4> NALCN channel mediates sodium leak currents and is important for maintaining proper resting membrane potential. NALCN and FAM155A form the core complex of the channel, the activity of which essentially depends on the presence of both UNC79 and UNC80, two auxiliary proteins. NALCN, FAM155A, UNC79, and UNC80 co-assemble into a large hetero-tetrameric channel complex. Genetic mutations of NALCN chan...

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Literature Corpus work: 2b024093-8ce2-5989-b1bc-a870c9426b32
DOI: 10.1101/2021.12.20.473568

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