Article
C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.
PloS one - 1 Jan 2013
Ng Chai Ann, Ke Ying, Perry Matthew D, Tan Peter S, Hill Adam P, Vandenberg Jamie I
Abstract excerpt
Kv11.1 potassium channels are important for regulation of the normal rhythm of the heartbeat. Reduced activity of Kv11.1 channels causes long QT syndrome type 2, a disorder that increases the risk of cardiac arrhythmias and sudden cardiac arrest. Kv11.1 channels are members of the KCNH subfamily of voltage-gated K(+) channels. However, they also share many similarities with the cyclic nucleotide gated ion channel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.