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Article

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge.

The Journal of general physiology - 6 Apr 2020

Ben-Bassat Ariel, Giladi Moshe, Haitin Yoni

Abstract excerpt

Human KCNH2 channels (hKCNH2, ether-à-go-go [EAG]-related gene, hERG) are best known for their contribution to cardiac action potential repolarization and have key roles in various pathologies. Like other KCNH family members, hKCNH2 channels contain a unique intracellular complex, consisting of an N-terminal eag domain and a C-terminal cyclic nucleotide-binding homology domain (CNBHD), which is crucial for...

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Identifiers

PMID: 32191791
DOI: 10.1085/jgp.201912505
PMCID: PMC7141593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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