Article

Refinement of a Cryo-EM Structure of hERG: Bridging Structure and Function

2020-09-11

Abstract excerpt

The human ether-a-go-go -related gene (hERG) encodes the voltage gated potassium channel (KCNH2 or Kv11.1, commonly known as hERG). This channel plays a pivotal role in the stability of phase 3 repolarization of the cardiac action potential. Although a high-resolution cryo-EM structure is available for its depolarized (open) state, the structure surprisingly did not feature many functionally important interaction...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33349b5c-aa55-5ea4-9c8e-e43d12fc136e
DOI: 10.1101/2020.09.11.293266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Refinement of a Cryo-EM Structure of hERG: Bridging Structure and FunctionDOI 10.1101/2020.09.11.293266Read

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridgeSemantic proximity Read

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Semantic proximity Read

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channelSemantic proximity Read

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge.Semantic proximity Read

To be or not to be an ion channel: cryo-EM structures have a saySemantic proximity Read

Structural modeling of the hERG potassium channel and associated drug interactionsSemantic proximity Read

Catching the next wave of recombinant RyR2 cryo-EM structures. Commentary on "Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations".Semantic proximity Read

Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium ChannelsSemantic proximity Read

Potassium dependent structural changes in the selectivity filter of HERG potassium channelsSemantic proximity Read

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.Semantic proximity Read

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domainSemantic proximity Read

Structural basis of human Nav1.5 gating mechanismsSemantic proximity Read