Article

A molecular switch in RCK2 triggers sodium-dependent activation of K <sub>Na</sub> 1.1 (KCNT1) potassium channels

2023-09-29

Abstract excerpt

The Na + -activated K + channel K Na 1.1, encoded by the KCNT1 gene, is an important regulator of neuronal excitability. How intracellular Na + ions bind and increase channel activity is not well understood. Analysis of K Na 1.1 channel structures indicate that there is a large twisting of the βN-αQ loop in the intracellular RCK2 domain between the inactive and Na + -activated conformations, with a lysine (...

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Literature Corpus work: 615251ec-91f1-53dd-85fe-79f16ec42b97
DOI: 10.1101/2023.09.28.559907

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