Article

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism

2023-08-15

Abstract excerpt

<h4>ABSTRACT</h4> CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion homeostasis in many different mammalian tissues and cell types. Among the nine mammalian CLC homologs, CLC-2 is uniquely activated by hyperpolarization, rather than depolarization, of the plasma membrane. The molecular basis for the divergence in polarity of voltage gating mechanisms among closely relat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a027f463-2fd9-56f6-9269-b9b81ef85008
DOI: 10.1101/2023.08.13.553136

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanismDOI 10.1101/2023.08.13.553136Read

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeationSemantic proximity Read

Structure of the human ClC-1 chloride channelSemantic proximity Read

Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating.Semantic proximity Read

Mechanistic Elucidation of CLIC1 Membrane Insertion via Structural and Dynamic ModulationSemantic proximity Read

CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.Semantic proximity Read

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscsSemantic proximity Read

To be or not to be an ion channel: cryo-EM structures have a saySemantic proximity Read

The voltage-dependent ClC-2 chloride channel has a dual gating mechanism.Semantic proximity Read

Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride ChannelsSemantic proximity Read

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridgeSemantic proximity Read

Structure and function of ClC chloride channels.Semantic proximity Read

KCC2 transport activity requires the highly conserved L₆₇₅ in the C-terminal β1 strand.Semantic proximity Read