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Article

Structure of the carboxy-terminal region of a KCNH channel.

Nature - 9 Jan 2012

Brelidze Tinatin I, Carlson Anne E, Sankaran Banumathi, Zagotta William N

Abstract excerpt

The KCNH family of ion channels, comprising ether-à-go-go (EAG), EAG-related gene (ERG), and EAG-like (ELK) K(+)-channel subfamilies, is crucial for repolarization of the cardiac action potential, regulation of neuronal excitability and proliferation of tumour cells. The carboxy-terminal region of KCNH channels contains a cyclic-nucleotide-binding homology domain (CNBHD) and C-linker that couples the CNBHD to the...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22230959
DOI: 10.1038/nature10735
PMCID: PMC3267858

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Structure of the carboxy-terminal region of a KCNH channel.PMID 22230959Read ↗

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Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Semantic proximity Read ↗

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