Article

Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminus

2025-07-25

Abstract excerpt

Human NHE6 (HsNHE6) is an endosomal Na+/H+ exchanger essential for maintaining luminal pH and endo-lysosomal trafficking in neurons. HsNHE6 mutations are implicated in devastating neurological syndromes, but mechanistically the transporter remains poorly understood. Here, we present the single particle cryo-electron microscopy structure of HsNHE6 at 3.4 A, captured in an inward-open conformation. The structure rev...

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Literature Corpus work: b10b9f43-c77f-5fbe-8d3e-2e6111f84042
DOI: 10.1101/2025.07.21.665523

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Integrative structural analysis of the human endosomal Na⁺/H⁺ exchanger NHE6 reveals a lipid-stabilized intracellular gate and a disordered C-terminusDOI 10.1101/2025.07.21.665523Read

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