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Article

Structure of the C-terminal region of an ERG channel and functional implications.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2013

Brelidze Tinatin I, Gianulis Elena C, DiMaio Frank, Trudeau Matthew C, Zagotta William N

Abstract excerpt

The human ether-à-go-go-related gene (hERG) encodes a K(+) channel crucial for repolarization of the cardiac action potential. EAG-related gene (ERG) channels contain a C-terminal cyclic nucleotide-binding homology domain coupled to the pore of the channel by a C-linker. Here, we report the structure of the C-linker/cyclic nucleotide-binding homology domain of a mosquito ERG channel at 2.5-Å resolution. The...

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Identifiers

PMID: 23801759
DOI: 10.1073/pnas.1306887110
PMCID: PMC3710865

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structure of the C-terminal region of an ERG channel and functional implications.PMID 23801759Read ↗

Structure of the carboxy-terminal region of a KCNH channel.Semantic proximity Read ↗

Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Semantic proximity Read ↗

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Semantic proximity Read ↗

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction.Semantic proximity Read ↗

The S4-S5 linker acts as a signal integrator for HERG K+ channel activation and deactivation gating.Semantic proximity Read ↗

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge.Semantic proximity Read ↗

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read ↗

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Semantic proximity Read ↗

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.Semantic proximity Read ↗

Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridgeSemantic proximity Read ↗

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Semantic proximity Read ↗

Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel.Semantic proximity Read ↗

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