Article

Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4

2025-02-01

Abstract excerpt

<h4>SUMMARY</h4> Histone deacetylase inhibitors have been investigated as potential therapeutic agents for cancer and other diseases. HDIs are known to promote histone acetylation, resulting in an open chromatin conformation and generally increased gene expression. In previous work, we reported that a subset of genes, particularly those regulated by superenhancers, can be suppressed by the HDAC inhibitor largazol...

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Literature Corpus work: ace21684-c5e5-5803-859e-0e03f11b0ee0
DOI: 10.1101/2025.01.29.635612

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Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4DOI 10.1101/2025.01.29.635612Read

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