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Article

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains

13 Dec 2018

Abstract excerpt

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the interactomes of BRD2, BRD3, BRD4, and BRDT following treatment with the pan-BET BRD inhibitor JQ1, revealing broad rewiring of the interaction landscape, with three distinct classes of behavior for the 603 unique interactors identified. A...

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PMID: 30554943
DOI: 10.1016/j.molcel.2018.11.006

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