Article

BRD4 recruitment desilences transcription without erasure or depletion of repressive chromatin

2026-04-13

Abstract excerpt

How genes are desilenced within mesoscale repressive chromatin is a crucial yet poorly understood phenomenon. Prevailing models posit that methylation of lysine-9 of histone H3 (H3K9me3) engages heterochromatin protein 1 (HP1) to drive chromatin compaction and transcriptional silencing. The erasure of this repressive mark and its replacement with acetyl/acyl groups recruits positive factors such as BRD4/BET to eli...

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Literature Corpus work: 8ae63209-5da7-5c90-a9b9-e697e24aca7a
DOI: 10.64898/2026.04.10.717856

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