Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure–Activity Relationships

8 Nov 2017

Abstract excerpt

Since the time of its identification, the natural compound largazole rapidly caught the attention of the medicinal chemistry community for its impressive potency as an inhibitor of histone deacetylases (HDACs) and its strong antiproliferative activity against a broad panel of cancer cell lines. The design of largazole analogues is an expanding field of study, due to their remarkable potential as novel anticancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Histone Deacetylase Inhibitors Research
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29117473
DOI: 10.1002/cmdc.201700563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure–Activity RelationshipsPMID 29117473Read ↗

Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agentsSemantic proximity Read ↗

Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy.Semantic proximity Read ↗

Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluationSemantic proximity Read ↗

Natural Bioactive Compounds Targeting Histone Deacetylases in Human Cancers: Recent UpdatesSemantic proximity Read ↗

Structure-Based Inhibitor Discovery of Class I Histone Deacetylases (HDACs)Semantic proximity Read ↗

Targeting histone deacetylases for the treatment of cancer and inflammatory diseasesSemantic proximity Read ↗

Histone deacetylase inhibitors: a patent review (2009 – 2011)Semantic proximity Read ↗

Medicinal chemistry advances in targeting class I histone deacetylasesSemantic proximity Read ↗

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding GroupsSemantic proximity Read ↗

Role of Selective Histone Deacetylase 6 Inhibitor ACY-1215 in Cancer and Other Human DiseasesSemantic proximity Read ↗

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding GroupsSemantic proximity Read ↗

Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.