Article

KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

2020-07-03

Abstract excerpt

<h4>ABSTRACT</h4> The H3K27me2/me3 histone demethylase KDM6B is over-expressed in neuroblastoma and is essential to neuroblastoma cell survival. While the KDM6B inhibitor, GSK-J4, has shown activity in in vitro and in vivo preclinical models, the mechanism of action remains poorly defined. We demonstrate that genetic and pharmacologic inhibition of KDM6B downregulates the pRB-E2F transcriptome and MYCN express...

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Literature Corpus work: 7bd08f0a-1aa5-5412-9381-d9ddeb3420f3
DOI: 10.1101/2020.07.02.184986

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