Article

Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

2023-06-05

Abstract excerpt

Polygenic risk scores (PRS) have improved in predictive performance supporting their use in clinical practice. Reduced predictive performance of PRS in diverse populations can exacerbate existing health disparities. The NHGRI-funded eMERGE Network is returning a PRS-based genome-informed risk assessment to 25,000 diverse adults and children. We assessed PRS performance, medical actionability, and potential clinica...

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Literature Corpus work: acdc6f7e-2020-5196-905d-d65e44bfffba
DOI: 10.1101/2023.05.25.23290535

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