Article
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations.
Nature medicine - 1 Feb 2024
Lennon Niall J, Kottyan Leah C, Kachulis Christopher, Abul-Husn Noura S, Arias Josh, Belbin Gillian, Below Jennifer E, Berndt Sonja I, Chung Wendy K, Cimino James J, Clayton Ellen Wright, Connolly John J, Crosslin David R, Dikilitas Ozan, Velez Edwards Digna R, Feng QiPing, Fisher Marissa, Freimuth Robert R, Ge Tian, Glessner Joseph T, Gordon Adam S, Patterson Candace, Hakonarson Hakon, Harden Maegan, Harr Margaret, Hirschhorn Joel N, Hoggart Clive, Hsu Li, Irvin Marguerite R, Jarvik Gail P, Karlson Elizabeth W, Khan Atlas, Khera Amit, Kiryluk Krzysztof, Kullo Iftikhar, Larkin Katie, Limdi Nita, Linder Jodell E, Loos Ruth J F, Luo Yuan, Malolepsza Edyta, Manolio Teri A, Martin Lisa J, McCarthy Li, McNally Elizabeth M, Meigs James B, Mersha Tesfaye B, Mosley Jonathan D, Musick Anjene, Namjou Bahram, Pai Nihal, Pesce Lorenzo L, Peters Ulrike, Peterson Josh F, Prows Cynthia A, Puckelwartz Megan J, Rehm Heidi L, Roden Dan M, Rosenthal Elisabeth A, Rowley Robb, Sawicki Konrad Teodor, Schaid Daniel J, Smit Roelof A J, Smith Johanna L, Smoller Jordan W, Thomas Minta, Tiwari Hemant, Toledo Diana M, Vaitinadin Nataraja Sarma, Veenstra David, Walunas Theresa L, Wang Zhe, Wei Wei-Qi, Weng Chunhua, Wiesner Georgia L, Yin Xianyong, Kenny Eimear E
Abstract excerpt
Polygenic risk scores (PRSs) have improved in predictive performance, but several challenges remain to be addressed before PRSs can be implemented in the clinic, including reduced predictive performance of PRSs in diverse populations, and the interpretation and communication of genetic results to both providers and patients. To address these challenges, the National Human Genome Research Institute-funded...
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