Article

Clinical validation, implementation, and reporting of polygenic risk scores for common diseases

2021-08-09

Abstract excerpt

<title>Abstract</title> <p>Implementation of polygenic risk scores (PRS) may improve disease prevention and management but requires the construction and validation of clinical assays, interpretation, and reporting pipelines. We developed a clinical genotype array-based assay for published PRS for 6 common diseases. First, we calculated PRS for 36,423 Mass General Brigham Biobank (MGBB) participants. Finding signi...

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Literature Corpus work: afcfebf8-670e-582c-ba47-c7d5f699ddea
DOI: 10.21203/rs.3.rs-743779/v1

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