Article
Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2023
Hui Daniel, Xiao Brenda, Dikilitas Ozan, Freimuth Robert R, Irvin Marguerite R, Jarvik Gail P, Kottyan Leah, Kullo Iftikhar, Limdi Nita A, Liu Cong, Luo Yuan, Namjou Bahram, Puckelwartz Megan J, Schaid Daniel, Tiwari Hemant, Wei Wei-Qi, Verma Shefali, Kim Dokyoon, Ritchie Marylyn D
Abstract excerpt
Polygenic risk scores (PRS) have led to enthusiasm for precision medicine. However, it is well documented that PRS do not generalize across groups differing in ancestry or sample characteristics e.g., age. Quantifying performance of PRS across different groups of study participants, using genome-wide association study (GWAS) summary statistics from multiple ancestry groups and sample sizes, and using different...
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