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Article

Development and Validation of a Clinical Polygenic Risk Report in U.S.-Based Health Systems for 8 Cardiovascular Conditions.

Journal of the American College of Cardiology - 8 Sept 2026

Misra Anika, Jowell Amanda, Haidermota Sara, Perez Emma, Mahanta Lisa, O'Brien Kimberly J, Nagy Anna, Hao Limin, Truong Buu, Aragam Krishna, Fahed Akl C, Khurshid Shaan, Ellinor Patrick T, Lewis Anna C F, Lennon Niall, Hornsby Whitney, Lebo Matthew S, Karlson Elizabeth W, Natarajan Pradeep, Patel Aniruddh P

Abstract excerpt

BACKGROUND: Polygenic risk scores (PRS) stratify inherited cardiovascular risk, but their path to clinical implementation remains unclear. OBJECTIVES: We aimed to develop and validate integrated PRS for 8 cardiovascular conditions and outline a framework for their clinical reporting. METHODS: We analyzed genotype and clinical data from 245,394 All of Us Research Program participants. Publicly available PRS for 8...

Read the complete abstract on PubMed

Topics

Humans
Female
Genetic Risk Score
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

United States

Male

Cardiovascular Diseases

Risk Assessment

Hypercholesterolemia

Diabetes Mellitus, Type 2

Adult

Aortic Aneurysm, Thoracic

Genetic Predisposition to Disease

Hypertension

Aged

Coronary Artery Disease

Venous Thromboembolism

Lipoprotein(a)

Source

Open in PubMed Open full text

Identifiers

PMID: 42053472
DOI: 10.1016/j.jacc.2026.03.035
PMCID: PMC13380837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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