Article
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.
Nature communications - 1 Oct 2025
Guo Boya, Cai Yanwei, Kim Daeeun, Smit Roelof A J, Wang Zhe, Iyer Kruthika R, Hilliard Austin T, Haessler Jeffrey, Tao Ran, Broadaway K Alaine, Wang Yujie, Pozdeyev Nikita, Stæger Frederik F, Yang Chaojie, Vanderwerff Brett, Patki Amit D, Stalbow Lauren, Lin Meng, Rafaels Nicholas, Shortt Jonathan, Wiley Laura, Stanislawski Maggie, Pattee Jack, Davis Lea, Straub Peter S, Shuey Megan M, Cox Nancy J, Lee Nanette R, Jørgensen Marit E, Bjerregaard Peter, Larsen Christina, Hansen Torben, Moltke Ida, Meigs James B, Stram Daniel O, Yin Xianyong, Zhou Xiang, Chang Kyong-Mi, Clarke Shoa L, Guarischi-Sousa Rodrigo, Lankester Joanna, Tsao Philip S, Buyske Steven, Graff Mariaelisa, Raffield Laura M, Sun Quan, Wilkens Lynne R, Carlson Christopher S, Easton Charles B, Liu Simin, Manson JoAnn E, Marchand Loïc L, Haiman Christopher A, Mohlke Karen L, Gordon-Larsen Penny, Albrechtsen Anders, Boehnke Michael, Rich Stephen S, Manichaikul Ani, Rotter Jerome I, Yousri Noha A, Irvin Ryan M, Gignoux Chris, North Kari E, Loos Ruth J F, Assimes Themistocles L, Peters Ulrike, Kooperberg Charles, Raghavan Sridharan, Highland Heather M, Darst Burcu F
Abstract excerpt
Polygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations across various contexts. We systematically characterize a multi-ancestry type 2 diabetes polygenic risk score among 244,637 cases and 637,891 controls across diverse...
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