Article

Scalable multimodal mapping of macrophage regulatory architecture by integrating optical and transcriptomic pooled screens

2026-05-29

Abstract excerpt

<h4>ABSTRACT</h4> Understanding how genetic perturbations reshape cellular states requires measuring diverse phenotypic modalities at scale. Here, we present PerturbPair, a platform that combines parallel Perturb-Seq and optical pooled screening (OPS) in primary mouse bone marrow-derived macrophages stimulated with lipopolysaccharide. Profiling over 334,000 single-cell transcriptomes across ∼1,000 gene perturbati...

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Literature Corpus work: ac0aa1ee-88f8-5595-b1f2-5a905b1cb967
DOI: 10.64898/2026.05.27.728345

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