A Pooled Cell Painting CRISPR Screening Platform Enables de novo Inference of Gene Function by Self-supervised Deep Learning

Abstract excerpt

Pooled CRISPR screening has emerged as a powerful method of mapping gene functions thanks to its scalability, affordability, and robustness against well or plate-specific confounders present in array-based screening 1–6 . Most pooled CRISPR screens assay for low dimensional phenotypes (e.g. fitness, fluorescent markers). Higher-dimensional assays such as perturb-seq are available but costly and only applicable to...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Cas Systems
• Gene Library
• Genetic Testing
• High-Throughput Nucleotide Sequencing
• Image Processing, Computer-Assisted
• Lentivirus
• Phenotype

Identifiers and source

Literature Corpus work

a86195bb-15aa-5bbd-9458-a8562393ffa2

DOI

10.1101/2023.08.13.553051