Article

Comparing phenotypic manifolds with Kompot: Detecting differential abundance and gene expression at single-cell resolution

2025-06-07

Abstract excerpt

Single-cell studies are frequently designed to compare across conditions such as health and disease. However, existing computational approaches typically rely on grouping cells into discrete populations before making comparisons, which can limit resolution for detecting state-dependent changes. Here, we introduce Kompot, a statistical framework for comparative analysis of multi-condition single-cell data. Kompot q...

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Literature Corpus work: 7eb98fee-bf27-55eb-bc2c-b9895f57821d
DOI: 10.1101/2025.06.03.657769

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