Article

Compressed phenotypic screens for complex multicellular models and high-content assays

2023-01-23

Abstract excerpt

High-throughput phenotypic screens leveraging biochemical perturbations, high-content readouts, and complex multicellular models could advance therapeutic discovery yet remain constrained by limitations of scale. To address this, we establish a method for compressing screens by pooling perturbations followed by computational deconvolution. Conducting controlled benchmarks with a highly bioactive small molecule lib...

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Literature Corpus work: f8ed287b-8ccf-531c-b499-e97f899a6141
DOI: 10.1101/2023.01.23.525189

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