Article

X-Cell: Scaling Causal Perturbation Prediction Across Diverse Cellular Contexts via Diffusion Language Models

2026-03-20

Abstract excerpt

Causal models of cellular systems hold the promise to empower broad biological discovery, including the systematic identification of novel targets for drug discovery. Predicting how genetic and pathway perturbations reshape gene expression across diverse cellular contexts is a prerequisite for building generalizable cellular foundation models. However, current methods typically fail to extrapolate beyond their tra...

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Literature Corpus work: eafe63b6-ae0b-5f3c-b14b-8739f2b2d520
DOI: 10.64898/2026.03.18.712807

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