Seq-Scope-eXpanded: Spatial Omics Beyond Optical Resolution

Abstract excerpt

Sequencing-based spatial transcriptomics (sST) enables transcriptome-wide gene expression mapping but falls short of reaching the optical resolution (200–300 nm) of imaging-based methods. Here, we present Seq-Scope-X (Seq-Scope-eXpanded), which empowers submicrometer-resolution Seq-Scope with tissue expansion to surpass this limitation. By physically enlarging tissues, Seq-Scope-X minimizes transcript diffusion ef...

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• Liver Disease Diagnosis and Treatment
• Liver physiology and pathology
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

ba55544f-9bcf-5e87-95ad-1125ff2c32d3

DOI

10.1101/2025.02.04.636355