Article

ERK2-topoisomerase II regulatory axis is important for gene activation in immediate early genes

2022-08-09

Abstract excerpt

<h4>ABSTRACT</h4> The transcription of stress-inducible genes requires synchronized and robust activation, which is critical for organismal survival and homeostasis. The function of the mitogen-activated protein kinase (MAPK) signaling pathway is required for the activation of immediate early genes (IEGs), including EGR1 and FOS , for cell growth and proliferation 1–3 . In addition, recent studies have identif...

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Literature Corpus work: abcfac36-5538-52f0-8937-aad631466da0
DOI: 10.1101/2022.08.09.503353

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