Article

Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing

2024-06-06

Abstract excerpt

The eukaryotic microrchidia (MORC) protein family are DNA g yrase, H sp90, histidine k inase, Mut L (GHKL)-type ATPases involved in gene expression regulation and chromatin compaction. The molecular mechanisms underlying these activities are incompletely understood. Here we studied the full-length human MORC2 protein biochemically. We identified a DNA binding site in the C-terminus of the protein, and we obser...

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Literature Corpus work: 0a7f1e28-ddb6-56ea-849e-b6c4b73a60a2
DOI: 10.1101/2024.06.05.597643

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