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Article

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

Molecular and cellular biology - 1 May 1999

Shapiro P S, Whalen A M, Tolwinski N S, Wilsbacher J, Froelich-Ammon S J, Garcia M, Osheroff N, Ahn N G

Abstract excerpt

The mitogen-activated protein (MAP) kinases, extracellular signal-related kinase 1 (ERK1) and ERK2, regulate cellular responses by mediating extracellular growth signals toward cytoplasmic and nuclear targets. A potential target for ERK is topoisomerase IIalpha, which becomes highly phosphorylated during mitosis and is required for several aspects of nucleic acid metabolism, including chromosome condensation and...

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Identifiers

PMID: 10207078
DOI: 10.1128/MCB.19.5.3551
PMCID: PMC84147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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