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DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells

22 Sept 2021

Abstract excerpt

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is known primarily for its function in DNA double-stranded break repair and nonhomologous end joining (NHEJ). However, DNA-PKcs also has a critical yet undefined role in immunity impacting both myeloid and lymphoid cell lineages spurring interest in targeting DNA-PKcs for therapeutic strategies in immune-related diseases. To gain insight into the function...

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PMID: 34562454
DOI: 10.1016/j.jbc.2021.101209

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