Histone H3 phosphorylation, immediate-early gene expression, and the nucleosomal response: a historical perspective¹This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal’s usual peer review process.

Abstract excerpt

Histone H3 is modified at serines 10 and 28 in interphase cells following activation of the RAS-MAPK or p38-MAPK pathways by growth factors or stress. These modifications are involved in the regulation of immediate-early genes, including Jun and Fos, whose increased expression is a trademark of various cancers. This review outlines the series of discoveries that led to the characterization of these modifications,...

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