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BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ

2020-12-12

Abstract excerpt

RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signaling in humans. Here, we report a novel function of the br east ca ncer 1 (BRCA1)- B RCA1 a ssociated r ing d omain 1 (BARD1) complex, in this process. We found that BRCA1 is phosphorylated at S1524 by the kinases ATM and A...

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Literature Corpus work
4df20e1a-a40b-55eb-a328-73fd937fcaa5
DOI
10.1101/2020.12.12.422337
Open publication

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BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβDOI 10.1101/2020.12.12.422337
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