Article

Estradiol Increases Risk of Topoisomerase Ⅱβ-Mediated DNA Strand Breaks to Initiate Xp11.2 Translocation Renal Cell Carcinoma

2021-06-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Xp11.2 translocation renal cell carcinoma (tRCC) is defined by translocation of the transcription factor E3 (<italic>TFE3</italic>) gene located on chromosome Xp11.2. Due to the high incidence in women, 17β-estradiol (E2) may be a factor influencing <italic>TFE3</italic> breaks, and the topoisomerase Ⅱ (TOP2) poison is considered one of the important risk factor...

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Literature Corpus work: d05fd749-152f-538d-97fe-e902f31d163c
DOI: 10.21203/rs.3.rs-554011/v1

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