Article

Novel DNA endonuclease activity of human ERK1 protein

2025-03-07

Abstract excerpt

ERK1 is a key kinase in the mitogen-activated protein kinase pathway, which transduces extracellular signals into cellular responses. Following triggering of the pathway, cytosolic ERK1 is phosphorylated, translocates into the nucleus, and activates DNA-bound transcription factors and target genes. This study reports a novel, non-canonical role of human ERK1 as a DNA endonuclease. It catalyzes single-strand DNA br...

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Literature Corpus work: d877b516-866a-5d76-b046-cb2bf256ffce
DOI: 10.1101/2025.03.03.641133

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