Article

DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells

2021-06-04

Abstract excerpt

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is known primarily for its function in DNA double-stranded break repair and non-homologous end joining (NHEJ). However, DNA-PKcs also has a critical yet undefined role in immunity impacting both myeloid and lymphoid cell lineages spurring interest in targeting DNA-PKcs for therapeutic strategies in immune-related diseases. To gain insight into the function...

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Literature Corpus work: 9ec9d7e1-aa78-5a1b-b766-fbc9416d38f6
DOI: 10.1101/2021.06.04.446996

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