Article

Computational Stabilization of the Human VH Germline Repertoire to Enable Conditional Multi-Specific Therapeutic Development

2025-11-03

Abstract excerpt

Protein-based biologic therapies, particularly antibody-like therapeutics, have emerged as a major modality to treat nearly all chronic and infectious diseases. Antagonists have dominated the first wave of antibody and antibody-like biologics, whereas agonism has generally been challenging due to systemic activation leading to issues with therapeutic index and problems with pleiotropic activity. Additionally, agon...

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Literature Corpus work: d30dbc93-bc89-5af5-9268-1b1bcb763f5a
DOI: 10.1101/2025.10.31.685826

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