Article

Molecular Insights into Ultra-Humanisation of mAbs: Crystal Structure of Ultra-Humanised anti-pTau Fab Reveals Unmodified Binding Interactions

2021-08-10

Abstract excerpt

Administration of therapeutic antibodies can elicit adverse immune responses in patients through the generation of anti-drug antibodies that, in turn, affect the efficacy of the therapeutic. Removal of foreign amino acid content by humanization can lower the immunogenic risk of the therapeutic mAb. We previously developed the ultra-humanization technology “Augmented Binary Substitution” which enables single-step C...

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Literature Corpus work: 2017901b-4d0d-55d7-9e78-9e595725a81d
DOI: 10.21203/rs.3.rs-751879/v1

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Molecular Insights into Ultra-Humanisation of mAbs: Crystal Structure of Ultra-Humanised anti-pTau Fab Reveals Unmodified Binding InteractionsDOI 10.21203/rs.3.rs-751879/v1Read

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