Article
Tuning antibody stability and function by rational designs of framework mutations.
mAbs - 1 Dec 2025
Ng Joseph C F, Chenoweth Alicia, De Sciscio Maria Laura, Grandits Melanie, Cheung Anthony, Chu Tooki, McCraw Alexandra, Chauhan Jitesh, Liu Yi, Guo Dongjun, Patel Semil, Kosmider Alice, Iancu Daniela, Karagiannis Sophia N, Fraternali Franca
Abstract excerpt
Artificial intelligence and machine learning models have been developed to engineer antibodies for specific recognition of antigens. These approaches, however, often focus on the antibody complementarity-determining region (CDR) whilst ignoring the immunoglobulin framework (FW), which provides structural rigidity and support for the flexible CDR loops. Here we present an integrated computational-experimental...
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