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Article

Computational design of antibody-affinity improvement beyond in vivo maturation.

Nature biotechnology - 1 Oct 2007

Lippow Shaun M, Wittrup K Dane, Tidor Bruce

Abstract excerpt

Antibodies are used extensively in diagnostics and as therapeutic agents. Achieving high-affinity binding is important for expanding detection limits, extending dissociation half-times, decreasing drug dosages and increasing drug efficacy. However, antibody-affinity maturation in vivo often fails to produce antibody drugs of the targeted potency, making further affinity maturation in vitro by directed evolution...

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Identifiers

PMID: 17891135
DOI: 10.1038/nbt1336
PMCID: PMC2803018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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