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Article

Assisted Design of Antibody and Protein Therapeutics (ADAPT).

PloS one - 1 Jan 2017

Vivcharuk Victor, Baardsnes Jason, Deprez Christophe, Sulea Traian, Jaramillo Maria, Corbeil Christopher R, Mullick Alaka, Magoon Joanne, Marcil Anne, Durocher Yves, O'Connor-McCourt Maureen D, Purisima Enrico O

Abstract excerpt

Effective biologic therapeutics require binding affinities that are fine-tuned to their disease-related molecular target. The ADAPT (Assisted Design of Antibody and Protein Therapeutics) platform aids in the selection of mutants that improve/modulate the affinity of antibodies and other biologics. It uses a consensus z-score from three scoring functions and interleaves computational predictions with experimental...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28750054
DOI: 10.1371/journal.pone.0181490
PMCID: PMC5531539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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