Article

Reliable energy-based antibody humanization and stabilization

2022-08-15

Abstract excerpt

Humanization is an essential step in developing animal-derived antibodies into therapeutics, and approximately one third of approved antibodies have been humanized. Conventional humanization approaches graft the complementarity-determining regions (CDRs) of the animal antibody onto several homologous human frameworks. This process, however, often drastically lowers stability and antigen binding, demanding iterativ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 464805dc-f092-5707-9fc0-d1e9e7622267
DOI: 10.1101/2022.08.14.503891

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reliable energy-based antibody humanization and stabilizationDOI 10.1101/2022.08.14.503891Read

AI-Guided Precision in Antibody Humanization: Structural Modeling to Minimize Immunogenicity and Preserve EfficacySemantic proximity Read

<i>Llamanade</i> : an open-source computational pipeline for robust nanobody humanizationSemantic proximity Read

Advances in computational structure-based antibody designSemantic proximity Read

<i>In silico</i> design of stable single-domain antibodies with high affinitySemantic proximity Read

Structure guided homology model based design and engineering of mouse antibodies for humanizationSemantic proximity Read

Antibody humanization methods – a review and updateSemantic proximity Read

Deep learning-based design and experimental validation of a medicine-like human antibody librarySemantic proximity Read

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.Semantic proximity Read

RosettaAntibodyDesign (RAbD): A General Framework for Computational Antibody DesignSemantic proximity Read

Humatch - fast, gene-specific joint humanisation of antibody heavy and light chainsSemantic proximity Read

Computational optimization of antibody humanness and stability by systematic energy-based rankingSemantic proximity Read

Antibody humanization by molecular dynamics simulations-in-silico guided selection of critical backmutations.Semantic proximity Read