Article

Structure-guided computational design and mechanistic understanding of the p95HER2-targeting NAZ-mAb antibody and its variants

2026-07-11

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2) is an oncogenic receptor tyrosine kinase in breast cancer and other malignancies. A subset of HER2-positive tumours expresses 611-CTF-p95HER2, a tumour-specific, hyperactive truncated isoform associated with metastasis and treatment resistance that lacks most of the extracellular domain targeted by conventional HER2-directed antibodies. We previously developed NAZ-mA...

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Literature Corpus work: a8564617-a643-5e9f-b2c3-bffa06564976
DOI: 10.64898/2026.07.07.736817

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