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Rational optimization of a monoclonal antibody for simultaneous improvements in its solution properties and biological activity.

Protein engineering, design & selection : PEDS - 1 Jul 2018

Kumar Sandeep, Roffi Kirk, Tomar Dheeraj S, Cirelli David, Luksha Nicholas, Meyer Danielle, Mitchell Jeffrey, Allen Martin J, Li Li

Abstract excerpt

Developability considerations should be integrated with lead engineering of antibody drug candidates in interest of their cost effective translations into medicines. To explore feasibility of this imperative, we have performed rational mutagenesis studies on a monoclonal antibody (MAB1) whose development was discontinued owing to manufacturability hurdles. Seven computationally designed variants of MAB1...

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PMID: 30189027
DOI: 10.1093/protein/gzy020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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