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Article

Molecular basis of the effect of potassium on heterologously expressed pacemaker (HCN) channels.

The Journal of physiology - 1 Mar 2003

Azene Ezana M, Xue Tian, Li Ronald A

Abstract excerpt

Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels modulate the firing rates of neuronal and cardiac pacemaker cells. HCN channels resemble voltage-gated K+ channels structurally, but much less is known about their structure-function correlation. Although modulation of K+ channel gating by external K+ is a well-known phenomenon, such a link has not been established for HCN channels. Here we...

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Source

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Identifiers

PMID: 12562911
DOI: 10.1113/jphysiol.2003.039768
PMCID: PMC2342664

Genes

HCN1
HCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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