Article

Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation

2024-01-09

Abstract excerpt

Human ether-à-go-go related gene (hERG) voltage-activated potassium channels are critical for cardiac excitability. Characteristic slow closing (deactivation) in hERG is regulated by direct interaction between the N-terminal Per-Arnt-Sim (PAS) domain and the C-terminal cyclic nucleotide binding homology domain (CNBHD). We aim to understand how the PAS domain that is distal to the pore rearranges during gating to a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69bd5f7e-9d40-5eb7-b0be-85797116ca37
DOI: 10.1101/2024.01.09.574834

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activationDOI 10.1101/2024.01.09.574834Read

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.Semantic proximity Read

Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.Semantic proximity Read

An Allosteric Model for Electromechanical Coupling in Cardiac CNBD ChannelsSemantic proximity Read

Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.Semantic proximity Read

A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.Semantic proximity Read

An intracellular hydrophobic nexus is critical for slow deactivation in hERG channelsSemantic proximity Read

Interactions between the N-terminal tail and the gating machinery of hERG K⁺ channels both in closed and open/inactive states.Semantic proximity Read

Probing the molecular basis of hERG drug block with unnatural amino acids.Semantic proximity Read

Potassium dependent structural changes in the selectivity filter of HERG potassium channelsSemantic proximity Read

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Semantic proximity Read

State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen.Semantic proximity Read

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.Semantic proximity Read