Article
Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms.
eLife - 11 Sept 2024
Abdelaziz Reham, Tomczak Adam P, Neef Andreas, Pardo Luis A
Abstract excerpt
The KCNH family of potassium channels serves relevant physiological functions in both excitable and non-excitable cells, reflected in the massive consequences of mutations or pharmacological manipulation of their function. This group of channels shares structural homology with other voltage-gated K+ channels, but the mechanisms of gating in this family show significant differences with respect to the canonical...
Topics
- Ion Channel Gating
- Ether-A-Go-Go Potassium Channels
- Humans
- Animals
- Protein Domains
- Mutation
- ERG1 Potassium Channel