Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms.

eLife - 11 Sept 2024

Abdelaziz Reham, Tomczak Adam P, Neef Andreas, Pardo Luis A

Abstract excerpt

The KCNH family of potassium channels serves relevant physiological functions in both excitable and non-excitable cells, reflected in the massive consequences of mutations or pharmacological manipulation of their function. This group of channels shares structural homology with other voltage-gated K+ channels, but the mechanisms of gating in this family show significant differences with respect to the canonical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ERG1 Potassium Channel
Share to Ether-A-Go-Go Potassium Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ion Channel Gating

Share to Mutation

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 39259196
DOI: 10.7554/eLife.91420
PMCID: PMC11390113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms.PMID 39259196Read ↗

Fifty years of gating currents and channel gating.Semantic proximity Read ↗

An Allosteric Model for Electromechanical Coupling in Cardiac CNBD ChannelsSemantic proximity Read ↗

Inactivation of the Kv2.1 channel through electromechanical coupling.Semantic proximity Read ↗

C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.Semantic proximity Read ↗

The Functional Properties, Physiological Roles, Channelopathy and Pharmacological Characteristics of the Slack (KCNT1) Channel.Semantic proximity Read ↗

Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel ComplexesSemantic proximity Read ↗

Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation.Semantic proximity Read ↗

Dissection of the structure-function relationship of Nav channels.Semantic proximity Read ↗

Potassium channel opening: a subtle two-step.Semantic proximity Read ↗

Gating in CNGA1 channels.Semantic proximity Read ↗

Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.Semantic proximity Read ↗

Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 ChannelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.