Article
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability.
Nature structural & molecular biology - 1 Mar 2004
Wingo Tammy L, Shah Vikas N, Anderson Mark E, Lybrand Terry P, Chazin Walter J, Balser Jeffrey R
Abstract excerpt
Sodium channels initiate the electrical cascade responsible for cardiac rhythm, and certain life-threatening arrhythmias arise from Na(+) channel dysfunction. We propose a novel mechanism for modulation of Na(+) channel function whereby calcium ions bind directly to the human cardiac Na(+) channel (hH1) via an EF-hand motif in the C-terminal domain. A functional role for Ca(2+) binding was identified...
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