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Article

An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.

BMC biology - 5 Feb 2024

Liu Zhipei, Wang Feng, Yuan Hui, Tian Fuyun, Yang Chuanyan, Hu Fei, Liu Yiyao, Tang Meiqin, Ping Meixuan, Kang Chunlan, Luo Ting, Yang Guimei, Hu Mei, Gao Zhaobing, Li Ping

Abstract excerpt

BACKGROUND: Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) channel and the Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channel share high amino acid sequence similarity and identical domain structures. hERG conducts outward current and is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38317233
DOI: 10.1186/s12915-024-01833-0
PMCID: PMC11380439

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