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Article

Transancestral mapping of the MHC region in systemic lupus erythematosus identifies new independent and interacting loci at MSH5, HLA-DPB1 and HLA-G.

Annals of the rheumatic diseases - 1 May 2012

Fernando Michelle M A, Freudenberg Jan, Lee Annette, Morris David Lester, Boteva Lora, Rhodes Benjamin, Gonzalez-Escribano María Francisca, Lopez-Nevot Miguel Angel, Navarra Sandra V, Gregersen Peter K, Martin Javier, Vyse Timothy J

Abstract excerpt

OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic multisystem genetically complex autoimmune disease characterised by the production of autoantibodies to nuclear and cellular antigens, tissue inflammation and organ damage. Genome-wide association studies have shown that variants within the major histocompatibility complex (MHC) region on chromosome 6 confer the greatest genetic risk for SLE in European...

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Identifiers

PMID: 22233601
DOI: 10.1136/annrheumdis-2011-200808
PMCID: PMC3329227

Genes

MSH5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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