Article

<i>De novo</i> mutations implicate novel genes with burden of rare variants in Systemic Lupus Erythematosus

2017-05-17

Abstract excerpt

The omnigenic model of complex diseases stipulates that the majority of the heritability will be explained by the effects of common variation on genes in the periphery of core disease pathways. Rare variant associations, expected to explain far less of the heritability, may be enriched in core disease genes and thus will be instrumental in the understanding of complex disease pathogenesis and their potential thera...

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Literature Corpus work: e3663d6a-3877-5694-91a4-f2c883c74392
DOI: 10.1101/139238

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